Genes Dictate If Caffeine Keeps You Up All Night
Caffeine typically remains in the system for 4-6 hours on average (half-life), but genetic variations make some people slow metabolizers who retain it up to 8-10 hours, leading to extended alertness and sleep disruption.
- Variations in the CYP1A2 gene classify individuals as fast or slow caffeine metabolizers, affecting half-life.
- Average 4-6 hours, but slow metabolizers retain caffeine longer, up to 8-10 hours, disrupting sleep.
| Metric | Scientific Observation | Impact Magnitude | Source | ||
|---|---|---|---|---|---|
| Half-life | Averages 4-6 hours, varies by CYP1A2 genetics | Slow metabolizers: up to 8-10 hours retention | Lucas et al. (2022), Nutrients | ||
| Sleep Quality | Evening intake disrupts latency and deep stages | Prolonged alertness in slow metabolizers | Lucas et al. (2022), Nutrients | ||
| Clearance Factors | Smoking accelerates, contraceptives slow metabolism | Alters personal sensitivity | Study findings on physiological influences | ||
| Genetic Testing | CYP1A2 variants predict response | Improves timing for better sleep | Lucas et al. (2022), Nutrients |