Circadian and Dopamine Factors Drive Nighttime Worsening of Restless Legs Syndrome
Restless legs syndrome worsens at night primarily due to circadian rhythms in the brain that reduce dopamine activity and sensitivity, amplifying the urge to move, often compounded by iron deficiency and genetic factors.
- Natural brain cycles cause RLS symptoms to peak in the evening, reducing rest quality.
- Lower nighttime dopamine activity amplifies the irresistible urge to move legs.
| Factor | Scientific Observation | Impact Magnitude | ||
|---|---|---|---|---|
| Circadian Rhythms | Natural variations in brain dopamine sensitivity | Evening peak of RLS symptoms | ||
| Dopamine Dysfunction | Lower activity due to system impairment | Amplifies nighttime urge to move | ||
| Brain Iron Deficiency | Disrupts signaling in dopamine pathways | Worsens rest disruption at night | ||
| Genetic Factors | Influences on circadian clock genes | Heightens vulnerability after dark | ||
| Source: Garcia-Borreguero et al. (2024), The Lancet Neurology | RLS pathophysiology and circadian variations | Exacerbated nighttime symptoms |